Synthesis and Properties of pH-Responsive Polymers with Cadaverine Side Groups

A water-soluble monomer N¹-(4-vinylbenzyl)-pentane-1,5-diamine dihydrochloride (VBPDA) with cadaverine (1,5-pentanediamine) group was synthesized. pH-responsive polymer with cadaverine group was obtained by free radical polymerization of VBPDA using 4,4-azobis(4-cyanovaleric acid) (ACVA) as the initiator. The structure and molecular weight of the polymer were characterized by FTIR, ¹H-NMR and GPC-MALLS. Aggregation behavior of the polymer in aqueous solution was investigated by dynamic light scattering (DLS), UV-Vis and fluorescence measurements. The experimental results show that the fluorescence intensity of the aggregates decreases and the size of the aggregates increases with increasing pH due to the continuous dehydration of the cadaverine side groups.     

Poly(N-isopropylacrylamide)-based thermo-responsive surfaces with controllable cell adhesion

Poly(N-isopropylacrylamide) (PNIPAAm)-based thermo-responsive surfaces can switch their wettability (from wettable to non-wettable) and adhesion (from sticky to non-sticky) according to external temperature changes. These smart surfaces with switchable interfacial properties are playing increasingly important roles in a diverse range of biomedical applications; these controlling cell-adhesion behavior has shown great potential for tissue engineering and disease diagnostics. Herein we reviewed the recent progress of research on PNIPAAm-based thermo-responsive surfaces that can dynamically control cell adhesion behavior. The underlying response mechanisms and influencing factors for PNIPAAm-based surfaces to control cell adhesion are described first. Then, PNIPAAm-modified two-dimensional flat surfaces for cell-sheet engineering and PNIPAAm-modified three-dimensional nanostructured surfaces for diagnostics are summarized. We also provide a future perspective for the development of stimuli-responsive surfaces.     

Smart Coatings Prepared via MAPLE Deposition of Polymer Nanocapsules for Light-Induced Release

Herein, smart coatings based on photo-responsive polymer nanocapsules (NC) and deposited by laser evaporation are presented. These systems combine remotely controllable release and high encapsulation efficiency of nanoparticles with the easy handling and safety of macroscopic substrates. In particular, azobenzene-based NC loaded with active molecules (thyme oil and coumarin 6) were deposited through Matrix-Assisted Pulsed Laser Evaporation (MAPLE) on flat inorganic (KBr) and organic (polyethylene, PE) and 3D (acrylate-based micro-needle array) substrates. SEM analyses highlighted the versatility and performance of MAPLE in the fabrication of the designed smart coatings. DLS analyses, performed on both MAPLE- and drop casting-deposited NC, demonstrated the remarkable adhesion achieved with MAPLE. Finally, thyme oil and coumarin 6 release experiments further demonstrated that MAPLE is a promising technique for the realization of photo-responsive coatings on various substrates.     

Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.     

食堂智能卡管理系统

本文全面介绍了通过使用最新推出的智能卡(IC卡)技术，结合51系列单片机而研制的食堂智能卡管理系统，替代了原食堂繁琐的饭票流通，实现了食堂管理的电脑化.     

Thermomechanical properties of smart composites

The smart composite materials reinforced by SMA show a high performance and special deformation behavior. The thermomechanical constitutive formulas of the composites are derived by means of Eshelby's equivalent inclusion method and Mori-Tanaka's mean field concept. The interaction between the inclusion and crack and toughening mechanism are considered and the energy release rate of a crack in the smart composite is calculated. This work shows that there are the multiple mechanisms contributing to the toughening of the smart composite materials reinforced by SMA.This project is supported by the National Natural Science Foundation of China.     

基于彩色扫描仪的图像光谱重构

针对彩色扫描仪的特点,采用主元分析法(PCA)和反向传播(BP)人工神经网络(ANN)相结合的方法对图像光谱重构进行研究。选择IT8.7/2标准色卡作为训练样本,将该色卡中的另一组色靶作为检验样本以讨论不同网络结构以及不同主元数和训练样本数对光谱重构的影响,再以自然色系统(NCS)色卡为检验样本来分析不同种类的训练和检验样本与光谱重构性能的关系。实验结果表明,采用3-14-6网络结构和6个主元数是最佳选择,训练样本和扫描目标之间的一致性是基于彩色扫描仪图像光谱重构的关键所在。     

A new modified remote user authentication scheme using smart cards

In 2000, a remote user authentication scheme using smart cards was proposed and the masquerade attacks were proved successful on this scheme. Recently, Kumar has suggested the idea of check digits to overcome the above attacks with a new scheme that removes these threats well. In this paper it is pointed out that the weakness still exists in Kumar＇s scheme, and the intruder can login to the remote system through having some information. A new scheme which can overcome these attacks and appears more secure and efficient than Kumar＇s is presented.     

马尔可夫链模型在信用卡账户行为变化预测中的应用

对信用卡账户行为变化的监控是降低信用卡风险的关键.论文在构建马尔可夫模型的基础上,讨论了在信用卡账户无新增贷款、新增贷款固定不变和新增贷款发生周期性变化的情况下,如何预测信用卡账户不同状态的金额、已偿付态和坏账态的金额、全部应收款的现值及它们的方差计算等内容,为信用卡账户行为变化的预测、管理提供了方法和依据.